Expression of c-kit and p53 in Non-small Cell Lung Cancers / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 167-172, 2004.
Article
in English
| WPRIM
| ID: wpr-216211
ABSTRACT
PURPOSE:
Increasing experimental evidence indicates that abnormal expression of c-kit may be implicated in the pathogenesis of a variety of solid tumors. It has been reported that over 70% of small cell lung cancer (SCLC) contain the c-kit receptor. In the present study, a c-kit analysis has been extended to non-small cell lung cancer (NSCLC). The expressions of p53, vascular endothelial growth factor (VEGF) and cd34, in addition to c-kit, were evaluated to investigate the correlations between these proteins and to determine their potential relationships with the clinicopathological data. MATERIALS ANDMETHODS:
Paraffin-embedded tumor sections, obtained from 147 patients with NSCLC, were immunohistochemically investigated using anti-c-kit, anti- p53, anti-VEGF and anti-cd34 antibodies.RESULTS:
c-kit was expressed in 40 (27%) of the tumors examined 27% of the adenocarcinomas, 27% of the squamous cell carcinomas and 29% of the undifferentiated carcinomas. p53 and VEG F immunoreactivities were present in 107 (73%) and 110 (75%) carcinomas, respectively. Anti-cd34 was negative in all samples. No associations were established among these proteins. The c-kit, however, showed a strong correlation with the T factor T1 (n=11), 0%; T2 (n=49), 16% and T3 (n=87), 37% (p=.006).CONCLUSION:
It is suggested that in NSCLC c-kit is expressed relatively frequently and may become a therapeutic target for the patients with inoperable or recurrent c-kit positive tumors. The alterations in p53 probably constitute an early event, whereas the activated c-kit may contribute to tumor progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Carcinoma
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Carcinoma, Non-Small-Cell Lung
/
Proto-Oncogene Proteins c-kit
/
Vascular Endothelial Growth Factor A
/
Small Cell Lung Carcinoma
/
Lung
/
Lung Neoplasms
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2004
Type:
Article
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