The Therapeutic Effect of Drug in Parkinson's Disease
Journal of the Korean Neurological Association
;
: 19-25, 1989.
Article
in Korean
| WPRIM
| ID: wpr-216342
ABSTRACT
Two hundred and four patients with Parkinson's disease initially treated wth a combination of levodopa and carbidopa ( Sinement 25-250 ) and / or anticholinergic drugs. All patients responded initially to drug. Sixteen patients(7.8%) had 20 acute central nervous system side effects 8, dyskinesia 6, visual hallucination5, psychosis and 1, akathisia. The response to treatment usually was stable for the first one and a half to four years of drug therapy. Subsequently, over 50 percent of patients had therapeutic failure among 82 patients with long term drug therapy, fourteen(l7.0%) had 18 side effects 8, on-off phenomenon 4. Morning dystonia 3, dyskinesiaand 3, simultaneous dyskinesia with parkinsonism. None had diphasic dyskinesia or myoclonus. The prognosis of the demented parkinsonian was relatively poor. Two patients died due to pneumonia and ovarian carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Pneumonia
/
Prognosis
/
Psychomotor Agitation
/
Psychotic Disorders
/
Carbidopa
/
Levodopa
/
Central Nervous System
/
Parkinsonian Disorders
/
Dyskinesias
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Neurological Association
Year:
1989
Type:
Article
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