Prognostic Factors for Node-Negative Advanced Gastric Cancer after Curative Gastrectomy
Journal of Gastric Cancer
;
: 161-166, 2016.
Article
in English
| WPRIM
| ID: wpr-216435
ABSTRACT
PURPOSE:
Lymph node (LN) metastasis is the best prognostic indicator in non-distant metastatic advanced gastric cancer. This study aimed to assess the prognostic value of various clinicopathologic factors in node-negative advanced gastric cancer. MATERIALS ANDMETHODS:
We retrospectively analyzed the clinical records of 254 patients with primary node-negative stage T2~4 gastric cancer. These patients were selected from a pool of 1,890 patients who underwent radical resection at Memorial Jin-Pok Kim Korea Gastric Cancer Center, Inje University Seoul Paik Hospital between 1998 and 2008.RESULTS:
Of the 254 patients, 128 patients (50.4%), 88 patients (34.6%), 37 patients (14.6%), and 1 patient (0.4%) had T2, T3, T4a, and T4b tumors, respectively. In a univariate analysis, operation type, T-stage, venous invasion, tumor size, and less than 15 LNs significantly correlated with tumor recurrence and cumulative overall survival. In a multivariate logistic regression analysis, tumor size, venous invasion, and less than 15 LNs significantly and independently correlated with recurrence. In a multivariate Cox proportional hazards analysis, tumor size (hazard ratio [HR] 2.926; 95% confidence interval [CI] 1.173~7.300; P=0.021), venous invasion (HR 3.985; 95% CI 1.401~11.338; P=0.010), and less than 15 LNs (HR 0.092; 95% CI 0.029~0.290; P<0.001) significantly correlated with overall survival.CONCLUSIONS:
Node-negative gastric cancers recurred in 8.3% of the patients in our study. Tumor size, venous invasion, and less than 15 LNs reliably predicted recurrence as well as survival. Aggressive postoperative treatments and timely follow-ups should be considered in cases with these characteristics.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Stomach Neoplasms
/
Logistic Models
/
Retrospective Studies
/
Follow-Up Studies
/
Seoul
/
Gastrectomy
/
Korea
/
Lymph Nodes
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Gastric Cancer
Year:
2016
Type:
Article
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