Factors Associated with the Development of Anti-insulin Antibody in Diabetic Children / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 100-106, 2000.
Article
in Korean
| WPRIM
| ID: wpr-216461
ABSTRACT
PURPOSE:
Anti-insulin antibodies develop within several months of initiation of insulin therapy in most of diabetic patients. The purpose of this study is to observe the relationship between the clinical factors and development of anti-insulin antibodyMETHODS:
Serum was collected from 116 diabetic patients and 47 nondiabetic children for the measurement of anti-insulin antibody titer by radioimmunoassay (RIA). Retrospective analysis of the medical records of clinical factors were evaluated.RESULTS:
There was no relationship of anti-insulin antibody titer with age, duration, HbA1c, insulin dose, and BMI in diabetic children. There was no difference in anti-insulin antibody titer according to the sex, the presence of family history, the presence of DKA, the presence of complications, the presence of puberty, species of insulin, duration of disease in diabetic children. The titers of anti-insulin antibody were significantly higher in type 1 diabetic children(30.3+/-17.9% in type 1 and 16.5+/-7.0% in type 2, P7%. The positive rates of anti-insulin antibody were higher in male patients with diabetes(73.2% in male and 53.3% in female, P7%).CONCLUSION:
The results suggests that anti-insulin antibody developed more likely in type 1 DM and less likely in DM patients whose control had been good and who used less insulin doses, which remains to be studied further with more patients for longer duation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radioimmunoassay
/
Medical Records
/
Retrospective Studies
/
Puberty
/
Diabetic Ketoacidosis
/
Insulin
/
Antibodies
Type of study:
Observational study
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2000
Type:
Article
Similar
MEDLINE
...
LILACS
LIS