Normative Data on Serum Levels of IGF-I, IGFBP-3 in Healthy Korean Children: Effect of Age, Sex, Height, Body Mass Index, and Pubertal Maturation on the Serum Levels / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
;
: 75-82, 2000.
Article
in Korean
| WPRIM
| ID: wpr-216464
ABSTRACT
PURPOSE:
This study was undertaken to obtain the normative data on serum levels of IGF-I and IGFBP-3 in healthy Korean children and to evaluate the effects of age, sex, height, body mass index and pubertal maturation on the serum levels of IGF-I and IGFBP-3.METHODS:
This study included 301 healthy Korean subjects in pediatric age group. Serum levels of IGF-I and IGFBP-3 were measured twice using IRMA kit in each individual. The correlations between the serum levels of IGF-I or IGFBP-3 and age, auxological data or children's Tanner stages were evaluated.RESULTS:
Serum levels of IGF-I and IGFBP-3 increased in proportion to age progression, and their rates of increase were remarkable shortly before and during the puberty. The correlations between serum levels of IGF-1 and age, sex, height standard deviation scores, BMI, or pubertal maturation were significant(P<0.05). However, the serum levels of IGFBP-3 was correlated only with height standard deviation scores(P<0.05). There was a significant positive correlation between serum levels of IGF-1 and those of IGFBP-3(P<0.001).CONCLUSION:
Although IGF-I and IGFBP-3 assays can be utilized for the evaluation of endogenous growth hormone status, the effects of age, sex, BMI, height and pubertal development on the levels of IGF-I and IGFBP-3 must be considered. Therefore, these results would be helpful as a normative data for the growth evaluation of children in Korea.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Body Height
/
Insulin-Like Growth Factor I
/
Growth Hormone
/
Puberty
/
Insulin-Like Growth Factor Binding Protein 3
/
Korea
Limits:
Adolescent
/
Child
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of Korean Society of Pediatric Endocrinology
Year:
2000
Type:
Article
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