The Expression of Toll-like Receptors in Idiopathic Inflammatory Myopathies / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 118-124, 2007.
Article
in Korean
| WPRIM
| ID: wpr-216856
ABSTRACT
Objective:
To investigate the expression of toll-like receptor (TLR)-2, 4 and 9 in idiopathic inflammatory myopathies (IIMs).Methods:
The expression of TLR-2, 4 and 9 was measured by real-time RT-PCR and immunohistochemical stain (IHS) from muscle tissues in patients with IIMs and controls.Results:
The expression levels of TLR-2, 4 and 9 in IIMs were significantly higher than controls. TLR-2, 4 and 9 were mainly expressed on sarcolemma of muscle fibers, perimysial vascular endothelium and infiltrating inflammatory cells in dermatomyositis, whereas, they were mainly expressed on sarcolemma of muscle fibers, destructed muscle fibers, and enodmysial infiltrating inflammatory cells in polymyositis.Conclusion:
TLR-2, 4 and 9 were highly expressed in muscle tissue of IIMs. These results suggest that TLR-2, 4 and 9 play a role in pathogenesis of IIMs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sarcolemma
/
Endothelium, Vascular
/
Polymyositis
/
Dermatomyositis
/
Toll-Like Receptors
/
Myositis
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2007
Type:
Article
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