The Effect of Omega-3 Fatty Acid Supplementation on Cerebral Blood Flow and Vascular Resistance: A Preliminary Study / 대한임상신경생리학회지
Korean Journal of Clinical Neurophysiology
;
: 68-72, 2015.
Article
in English
| WPRIM
| ID: wpr-216868
ABSTRACT
BACKGROUND:
The effects of omega-3 polyunsaturated fatty acids (PUFAs) on cerebral vessels have not been clarified until now. Thus we investigated the efficacy of omega-3 PUFAs supplementation on cerebral blood flow velocity and vascular resistance via transcranial doppler (TCD).METHODS:
Consecutive twenty patients (13 male and 7 female) with at least 1 cerebrovascular risk factor or a known cerebrovascular disease were enrolled. Patients were treated with omega-3 PUFAs (1 g, two times per day) for 12 weeks. Cerebral blood flow velocity, resistance index, and pulsatile index were checked before and after 12 weeks of treatment using TCD.RESULTS:
The change of resistance index in right MCA (from 0.58 +/- 0.07 to 0.55 +/- 0.07, p = 0.042) and left PCA (from 0.56 +/- 0.07 to 0.53 +/- 0.06, p = 0.037) showed significant improvement after 12 weeks of omega-3 PUFAs treatment. The changes in other vessels, however, failed to show any significant changes compared to the baseline.CONCLUSIONS:
Omega-3 PUFAs treatment showed feasible efficacies for cerebral vascular resistances in this open label trial. To confirm these results, larger samples of patients and longer period of follow-up is warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vascular Resistance
/
Blood Flow Velocity
/
Passive Cutaneous Anaphylaxis
/
Risk Factors
/
Follow-Up Studies
/
Fatty Acids, Unsaturated
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Clinical Neurophysiology
Year:
2015
Type:
Article
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