Sensitivity and Specificity of Vi-Indirect Fluore scent Antibody Test in Diagnosis of Typhoid Fever / 감염
Korean Journal of Infectious Diseases
;
: 379-384, 1998.
Article
in Korean
| WPRIM
| ID: wpr-21695
ABSTRACT
BACKGROUND:
Typhoid fever is diagnosed by culture or serological study. The confirmative diagnosis of typhoid fever is made by culture of the causative orga-nism usually from body fluids. Serological test is a supportive diagnostic tool, which is useful for early dia-gnosis. In Severance Hospital, Vi-indirect fluorescent antibody test(Vi-IFAT) using the Vi-antigen of Salmo-nella typhi has been used in the diagnosis of typhoid fever since 1989. We investigated the test results from the past 7 years, in order to clarify the sensitivity and specificity of Vi-IFAT.METHODS:
A retrospective study was done on pa-tients whose chief complaint was fever and who were tested using Vi-IFAT in the Severance Hospital from 1989 to 1996. The positive value for Vi-IFAT was de- fined as 164 or higher.RESULTS:
The sensitivity and specificity of Vi-IFAT for typhoid fever was 94.4% and 95.1%, respectively. The positive and negative predictive values were 85.7% and 98.2% respectively. Positive rates of Vi-IFAT after fever onset increased with time and 68% were positive before the first week. From the first to the second week, 89.5% were positive and after the second week, 100% were positive.CONCLUSION:
Vi-IFAT is not only a valuable sero-logic test for the diagnosis of typhoid fever, but also useful in the early diagnosis of the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Typhoid Fever
/
Body Fluids
/
Serologic Tests
/
Retrospective Studies
/
Sensitivity and Specificity
/
Early Diagnosis
/
Diagnosis
/
Fever
Type of study:
Diagnostic study
/
Observational study
/
Screening study
Language:
Korean
Journal:
Korean Journal of Infectious Diseases
Year:
1998
Type:
Article
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