Canine Renal Homotransplantation: II. Pathologic Study in Imuran-treated Homografts / 대한비뇨기과학회지
Korean Journal of Urology
;
: 365-369, 1971.
Article
in Korean
| WPRIM
| ID: wpr-217138
ABSTRACT
As follow-up of Song's experiments reported previously, this study was undertaken to observe pathologic changes in Imuran-treated renal homografts in dogs. Mongrel dogs weighing 15 to 20 kilograms were used in all experiments. Renal transplants were exchanged between animals. Imuran was administered twice a day per oral with daily doses of 3mg. per kilogram of body weight, and the first dose was given 24 hours before renal transplantation. Transplanted kidney were removed on the postoperative 1st, 3rd, 7th, 14th. 20th, and 30th day, and the were examined microscopically with Hematoxylin-Eosin staining. As comparing with the results of Song's experiments which were untreated homotransplants, the appearance of characteristic microscopic changes of rejection (progressive destructive changes of vessels with infiltration of lymphocytes, polymorphonuclear leukocytes and plasma cell) was temporarily delayed and modified by Imuran administration, but ischemic changes developed imminently in later days.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Azathioprine
/
Body Weight
/
Lymphocytes
/
Follow-Up Studies
/
Kidney Transplantation
/
Allografts
/
Kidney
/
Neutrophils
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1971
Type:
Article
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