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A Case of Relapsing Granulomatosis with Polyangiitis Treated Successfully with Rituximab
Journal of Rheumatic Diseases ; : 257-260, 2014.
Article in Korean | WPRIM | ID: wpr-217191
ABSTRACT
Granulomatosis with polyangiitis (GPA) is a rare antineutrophil cytoplasmic antibody associated with systemic disease characterized by granulomas and vasculitis affecting small and medium vessels. Neurological manifestations in GPA are less frequent than classical manifestations, such as lung and kidney involvement, and cranial nerve palsies are much rarer. Cyclophosphamide and glucocorticoids have been conventionally administered as an initial induction immunosuppressive therapy for GPA. However, increasing evidence has demonstrated the efficacy and safety of rituximab, an anti-B cell monoclonal antibody, for the treatment of GPA. Herein, we describe a successful treatment of relapsing GPA with cranial nerve involvement using rituximab in a 56-year-old male patient who was previously treated with cyclophosphamide plus glucocorticoids.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vasculitis / Antibodies, Antineutrophil Cytoplasmic / Cranial Nerve Diseases / Cranial Nerves / Cyclophosphamide / Rituximab / Glucocorticoids / Granuloma / Kidney / Lung Limits: Humans / Male Language: Korean Journal: Journal of Rheumatic Diseases Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vasculitis / Antibodies, Antineutrophil Cytoplasmic / Cranial Nerve Diseases / Cranial Nerves / Cyclophosphamide / Rituximab / Glucocorticoids / Granuloma / Kidney / Lung Limits: Humans / Male Language: Korean Journal: Journal of Rheumatic Diseases Year: 2014 Type: Article