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Mitochondrial DNA Copy Number in the Patients of Korean Polycystic Ovary Syndrome (PCOS) / 대한불임학회지
Korean Journal of Fertility and Sterility ; : 245-251, 2006.
Article in Korean | WPRIM | ID: wpr-217375
ABSTRACT

OBJECTIVE:

We analyzed quantification of mitochondria DNA (mtDNA) to investigate the relationship of mitochondria and pathogenesis of PCOS. MATERIALS AND

METHODS:

Peripheral blood samples were collected from 28 patients with PCOS who were under the inclusion criteria for PCOS and from 28 healthy controls. Genomic DNA was used to analyze real-time PCR for mtDNA copy number quantification. The mtDNA copy number was compared between the control and PCOS groups. All data was expressed as mean +/- SD. Statistical analysis was assessed by t-test.

RESULTS:

In this study, the mtDNA CT was 11.67+/-0.422 in PCOS patients and 11.51+/-0.722 in control group, respectively. The mtDNA copy number was 1726410.71+/-407858.591 the patients of in PCOS and 2167887.51+/-252459.28 in control group (p=0.08), respectively.

CONCLUSION:

In our study, using real-time PCR, there was a tendency of lower mtDNA copy number in the patients of PCOS when comparing to the control group even though statistical difference was not significant. However, more extensive analysis is required to clarity relationship between mtDNA copy number and pathogenesis of PCOS.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycystic Ovary Syndrome / DNA / DNA, Mitochondrial / Real-Time Polymerase Chain Reaction / Mitochondria Limits: Humans Language: Korean Journal: Korean Journal of Fertility and Sterility Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polycystic Ovary Syndrome / DNA / DNA, Mitochondrial / Real-Time Polymerase Chain Reaction / Mitochondria Limits: Humans Language: Korean Journal: Korean Journal of Fertility and Sterility Year: 2006 Type: Article