Accuracy of an Interferon-gamma Release Assay to Detect Active Tuberculosis in Children: A Pilot Study / 소아감염
Korean Journal of Pediatric Infectious Diseases
;
: 48-53, 2011.
Article
in English
| WPRIM
| ID: wpr-217564
ABSTRACT
PURPOSE:
Early diagnosis of active tuberculosis (TB) in children is difficult. The widely used tuberculin skin test has low sensitivity and cross reactivity with non-tuberculous mycobacteria or Bacille Calmette-Guerin vaccination. Interferon gamma release assays have been shown good diagnostic accuracy for active in adults. But studies in children were limited. The purpose of this study was to examine the performance of enzyme-linked immunospot assay (ELISpot) as an initial test in the diagnosis of active tuberculosis in children.METHODS:
In a hospital-based study, we prospectively examined the performance of ELISPot in 33 children suspected of active TB. TB was confirmed bacteriologically or histologically.RESULTS:
Among 33 patients, 9 had active tuberculosis. When tested, they all had a positive test result from the ELISpot. The sensitivity and specificity of the assay were 100% (95% CI, 66.4-100%) and 95.8% (95% CI, 78.9-99.9%) respectively.CONCLUSION:
ELISpot might be an useful and improved clinical diagnostic method for the detection of active TB in children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tuberculin
/
Tuberculosis
/
Skin Tests
/
Pilot Projects
/
Prospective Studies
/
Sensitivity and Specificity
/
Interferon-gamma
/
Vaccination
/
Early Diagnosis
/
Enzyme-Linked Immunospot Assay
Type of study:
Diagnostic study
/
Observational study
/
Screening study
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
Korean Journal of Pediatric Infectious Diseases
Year:
2011
Type:
Article
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