Clinical Significances of Serum Soluble Fas and Soluble Fas Ligand in Chronic Hepatitis B / 대한간학회지
The Korean Journal of Hepatology
;
: 507-514, 2006.
Article
in Korean
| WPRIM
| ID: wpr-217636
ABSTRACT
BACKGROUND/AIMS:
Apoptosis via Fas/FasL system is thought to be involved in the development of hepatocyte death in viral hepatitis B. In chronic hepatitis C, sFas/sFasL system was reported to control liver injury induced by Fas/FasL mediated apoptosis. To determine the role of sFas/sFasL system in chronic hepatitis B, we analyzed serum sFas/sFasL in 58 HBV patients and 29 healthy controls.METHODS:
HBV patients were categorized into two groups; normal ALT (40 IU/L). Serum sFas/sFasL levels in HBV patients were measured by ELISA and was compared with those in 29 healthy controls. Serum ALT levels, histological activity, and Fas/FasL expression of liver were compared.RESULTS:
Chronic hepatitis B patients with elevated ALT had significantly higher serum sFas levels than those in healthy controls (P<0.01). Serum sFasL levels, however, were significantly lower than those in healthy controls (P<0.01). Patients with moderate to marked degree of inflammation and fibrosis had significantly higher serum sFas levels than those in healthy controls (P<0.05). Serum sFasL levels had no correlation with the hepatic histological activity. Serum sFas/sFasL levels also had no significant correlation with the Fas/FasL expression of liver.CONCLUSIONS:
Serum sFas/sFasL levels play a possible role in the pathogenesis of chronic hepatitis B. These results suggest that serum sFas levels might serve as a marker for estimating the degree of hepatic histological activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hepatitis B virus
/
Fas Receptor
/
Hepatitis B, Chronic
/
Fas Ligand Protein
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS