Evaluation of Rapid Assay (Tox A/B Quik Chek) for the Detection of Clostridium difficile Toxins A and B / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
;
: 112-116, 2008.
Article
in Korean
| WPRIM
| ID: wpr-217983
ABSTRACT
BACKGROUND:
Toxin immunoassay is widely used for rapid diagnosis of Clostridium difficile-associated diarrhea. The aim of this study was to evaluate the performance of Tox A/B Quik Chek test (TECHLAB, Blacksburg, VA, USA) compared to toxigenic culture.METHODS:
From September 2006 to August 2007, 959 stools were examined by Tox A/B Quik Chek test and toxigenic culture (C. difficile culture plus tcdB PCR using colonies obtained from culture).RESULTS:
Compared to the results of toxigenic culture, the sensitivity and specificity of Tox A/B Quik Chek test were 47.5% and 97.5%, respectively.CONCLUSION:
The sensitivity of Tox A/B Quik Chek test was not high, but the specificity was high. Although Tox A/B Quik Chek test alone is not sufficient to diagnose Clostridium difficile-associated diarrhea, it may aid rapid diagnosis, early treatment and prevention of nosocomial spread of the infection, if supplemented by C. difficile culture or tissue culture cytotoxin assay.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacterial Proteins
/
Bacterial Toxins
/
Boron Compounds
/
Immunoassay
/
Polymerase Chain Reaction
/
Clostridioides difficile
/
Immunoenzyme Techniques
/
Sensitivity and Specificity
/
Clostridium
/
Early Diagnosis
Type of study:
Diagnostic study
/
Screening study
Language:
Korean
Journal:
Korean Journal of Clinical Microbiology
Year:
2008
Type:
Article
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