Effect of Clonidine Pretreatment on the Cardiovascular Toxicity Induced by Inrravenous Bupivacaine in Rabbits / 대한마취과학회지
Korean Journal of Anesthesiology
; : 1532-1540, 1994.
Article
in Ko
| WPRIM
| ID: wpr-218152
Responsible library:
WPRO
ABSTRACT
This study was performed to evaluate the influence of clonidine pretreatment on the car- diovascular toxic effects of bupivacaine overdose induced by constant intravenous infusion. Thirty male rabbits were used for this study and they were divided into saline pretreatment group(15) and clonidine-pretreatment group(15). The changes of mean arterial pressure, heart rate and electrocardiogram by the bupivacaine-induced toxic effect during intravenous infusion of bupivacaine were observed. The results were as follows; 1. Mean arterial pressure was significantly decreased in clonidine-premedicated group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of mean arterial pressure were significantly prolonged in clonidine group compared with control group (P <0.001 ). 2. Heart rate was significantly decreased in clonidine group compared with control group (P<0.01) before infusion of bupivacaine, but the times occuring 25% and 50% decrease of heart rate were significantly prolonged in clonidine group compared with control group (P< 0.001). 3. The times occuring the first QRS modification and first dysrhythmia and the final systole were significantly prolonged in clonidine group compared with control group (P < 0.001). In conclusion, clonidine given prophylactically delays the cardiotoxicity caused by bupivacaine overdose snd does not accentuate the subsequent hypotension.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Systole
/
Infusions, Intravenous
/
Bupivacaine
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Clonidine
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Electrocardiography
/
Arterial Pressure
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Heart Rate
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Hypotension
Limits:
Animals
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Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Anesthesiology
Year:
1994
Type:
Article