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Histopathologic, Immunohistochemical, and Electron Microscopic Findings of Pigmented Skin Lesions Immediately after Q-switched Alexandrite Laser Treatment / 대한피부과학회지
Korean Journal of Dermatology ; : 1014-1021, 2003.
Article in Korean | WPRIM | ID: wpr-218225
ABSTRACT

BACKGROUND:

There have been only a few electron microscopic studies after laser treatment of pigmented skin lesions.

OBJECTIVE:

The purpose was to investigate the pathologic, immunohistochemical, and electron microscopic changes following Q-switched alexandrite laser treatment of pigmented skin lesions.

METHODS:

Three patients with acquired bilateral nevus of Ota-like macules, and 2 patients with cafeau lait macule were irradiated with Q-switched alexandrite laser. Forty biopsies were taken before and immediately after laser treatment. Hematoxylin-eosin, Fontana-Masson, and gp100 staining were performed for the evaluation of the histopathologic and immunohistochemical findings of the specimens. Electron microscopic findings were also evaluated.

RESULTS:

Histopathologically, suprabasilar separations were observed immediately after laser treatment. Vacuolar alterations of pigment-containing cells were frequently found in the epidermis and/or in the dermis. Fontana-Masson and gp100 staining positivity changed to negative or decreased in the epidermis immediately after laser treatment, while they changed to negative in the dermis. Ultrastructurally, epidermal pigment-containing cells frequently showed severe vacuolar changes in the cytoplasm, pyknotic nuclei, and vacuolated and/or fragmented melanosomes immediately after laser treatment. Dermal melanocytes frequently revealed vacuolated and/or fragmented melanosomes immediately after laser treatment.

CONCLUSION:

Histopathologic, immunohistochemical, and electron microscopic examination of pigmented skin lesions immediately after Q-switched alexandrite laser treatment demonstrated vacuolated or fragmented melanosomes and vacuolar alteration of pigment-containing cells in the epidermis and/or in the dermis, which suggested selective photothermolysis of melanosomes.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Biopsy / Dermis / Melanosomes / Cytoplasm / Epidermis / Lasers, Solid-State / Melanocytes / Nevus Limits: Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Skin / Biopsy / Dermis / Melanosomes / Cytoplasm / Epidermis / Lasers, Solid-State / Melanocytes / Nevus Limits: Humans Language: Korean Journal: Korean Journal of Dermatology Year: 2003 Type: Article