STAT3 expression is associated with poor survival in non-elderly adult patients with newly diagnosed multiple myeloma
Blood Research
;
: 293-299, 2017.
Article
in English
| WPRIM
| ID: wpr-21828
ABSTRACT
BACKGROUND:
Signal transducer and activator of transcription 3 (STAT3) is not only a key signaling molecule in the regulation of growth but is also involved in malignant transformation. We investigated the prognostic significance of STAT3 expression in 94 non-elderly adult patients (aged 38 to 65 yr) with newly diagnosed multiple myeloma (MM).METHODS:
Tumor cell-specific phosphotyrosine-STAT3 (PY-STAT3) expression at the time of diagnosis was evaluated with dual immunohistochemical (IHC) staining for PY-STAT3 and CD138.RESULTS:
PY-STAT3 positivity was detected in 10 patients (10.6%), including three who showed strong expression. PY-STAT3-positive patients had higher serum C-reactive protein and calcium levels at diagnosis than did PY-STAT3-negative patients. PY-STAT3 positivity had predictive value for poor progression-free survival (PFS; P=0.001) and overall survival (OS; P=0.003). Among the 60 patients who received frontline autologous stem cell transplantation, PY-STAT3-positive patients had poorer PFS than did PY-STAT3-negative patients (4.2 vs. 19.2 mo, respectively; P=0.013). Multivariate analysis identified PY-STAT3 expression as an independent prognostic factor for PFS (relative risk [RR]=2.706, P=0.014) and OS (RR=3.091, P=0.044).CONCLUSION:
These data show that PY-STAT3 positivity, as determined using dual IHC, is a marker of poor prognosis in non-elderly adult patients with MM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
C-Reactive Protein
/
Calcium
/
Multivariate Analysis
/
Disease-Free Survival
/
Stem Cell Transplantation
/
Diagnosis
/
STAT3 Transcription Factor
/
Multiple Myeloma
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Blood Research
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS