Downregulation of Peroxisome Proliferator-Activated Receptor (PPAR)alpha, PPARgamma, and Phosphoglycerate Mutase 2 in Prostate Cancer / 대한비뇨기과학회지
Korean Journal of Urology
;
: 661-666, 2006.
Article
in Korean
| WPRIM
| ID: wpr-218364
ABSTRACT
PURPOSE:
To evaluate whether factors related to lipid and glucose metabolism have a potential role in the progression of prostate cancer, we measured the mRNA levels of the peroxisome proliferator-activated receptor (PPAR), fatty acid elongase (ELOVL), and two glycolytic enzymes in prostate cancer (CaP) tissues. MATERIALS ANDMETHODS:
Prostate tissues, obtained from radical prostatectomy (n=10) and transurethral resection of prostate (n=18), were quickly frozen in liquid nitrogen for RNA measurements. Transcript signals of PPAR alpha, PPAR gamma, ELOVL2, ELOVL5, phosphoglycerate kinase 1 (PgK1) and phosphoglycerate mutase 2 (PgM2) were measured using a reverse-transcription polymerase chain reaction.RESULTS:
The transcript signals of PPAR alpha and PPAR gamma were down-regulated in CaP tissues. In addition, the mRNA level of PgM2 in CaP tissues was lower than that in benign prostatic hyperplasia (BPH) tissues. However, the messages for ELOVL2, ELOVL5, and PgK1 were not significantly changed.CONCLUSIONS:
These results suggest that lowering of the PPARalpha, PPARgamma and PgM2 messages may be involved in aberrant and uncontrolled prostate cell growth and differentiation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphoglycerate Kinase
/
Prostate
/
Prostatectomy
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
RNA
/
RNA, Messenger
/
Down-Regulation
/
Polymerase Chain Reaction
/
Phosphoglycerate Mutase
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2006
Type:
Article
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