Clinical Significance of Hypocitraturia in Patients with Nephrolithiasis / 대한비뇨기과학회지
Korean Journal of Urology
;
: 631-634, 2006.
Article
in Korean
| WPRIM
| ID: wpr-218370
ABSTRACT
PURPOSE:
Hypocitraturia is cited as one of the risk factors promoting stone formation or recurrence of nephrolithiasis. We estimated the relationship between hypocitraturia and other metabolic abnormalities, such as hypercalciuria, hyperuricosuria and hyperoxaluria. The effects of potassium citrate medication were also investigated. MATERIALS ANDMETHODS:
We selected 706 renal stone patients with hypocitraturia (<320mg/day), who had received extracorporeal shock wave lithotripsy (ESWL) treatment, and examined the relationship between hypocitraturia and other metabolic abnormalities according to sex and age. We also examined the increment effect of urinary citrate and stone-free rate following potassium citrate (Urocitra(R)) medication.RESULTS:
Complicated hypocitraturia (coexistence with other metabolic abnormalities) was found in 332 of the 706 patients (47.0%). Of the 706 patients, 242 (34.3%), 112 (15.9%) and 33 (4.7%) had hyperoxaluria, hyperuricosuria and hypercalciuria, respectively. Complicated hypocitraturia was higher in the male than female subjects, and was statistically significant (50.4% vs. 39.8%). In 287 (77%) of the 373 patients who received potassium citrate treatment, the urinary citrate level was increased. The mean urinary citrate level was significantly increased (142.5 vs. 336.2 mg/day) (p<0.01), but the stone free rate was not following the citrate treatment.CONCLUSIONS:
Potassium citrate was effective in increasing the urinary citrate level. However, prophylactic effects of potassium citrate against recurrent nephrolithiasis must be proved by appropriate comparative studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Shock
/
Hyperoxaluria
/
Lithotripsy
/
Risk Factors
/
Citric Acid
/
Potassium Citrate
/
Nephrolithiasis
/
Hypercalciuria
Type of study:
Etiology study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2006
Type:
Article
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