Plasma Total Homocysteine Level Is Associated with the Pulsatility Index of Cerebral Arteries in Lacunar Infarction
Yonsei Medical Journal
;
: 819-824, 2013.
Article
in English
| WPRIM
| ID: wpr-218491
ABSTRACT
PURPOSE:
The pulsatility index (PI), measured by transcranial Doppler (TCD), is a surrogate marker for distal vascular resistance in cerebral arteries, and elevated plasma total homocysteine (tHcyt) is regarded as a cause of ischemic stroke, including lacunar infarction. We investigated the relationship between the PI of cerebral arteries and plasma tHcyt in patients with lacunar infarction. MATERIALS ANDMETHODS:
Plasma tHcyt level and TCD examination were performed in 94 patients with lacunar infarction. Mean flow velocity (MFV) and PI were assessed at the ipsilateral middle cerebral artery (MCA) and contralateral MCA, relative to the infarction, and the basilar artery (BA). Multivariate regression analysis was conducted between log-transformed tHcyt levels (logHcyt) and the PI of individual arteries.RESULTS:
There was a significant correlation between logHcyt and the PI in all tested arteries (ipsilateral MCA r=0.21, p=0.03; contralateral MCA r=0.21, p=0.04; BA r=0.35, p=0.01). In multivariate regression analysis, this significance remained unchanged after adjusting for vascular risk factors, creatinine, hematocrit and platelet count (ipsilateral MCA beta=0.26, p=0.01; contralateral MCA beta=0.21, p=0.04; BA beta=0.39, p=0.001). There was no significant association between logHcyt and MFV of individual arteries.CONCLUSION:
A significant association between plasma tHcyt and the PI of cerebral arteries indicates that homocysteine plays a role in the increase of distal arterial resistance in lacunar infarction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vascular Resistance
/
Basilar Artery
/
Cerebral Arteries
/
Regression Analysis
/
Risk Factors
/
Ultrasonography, Doppler, Transcranial
/
Middle Cerebral Artery
/
Stroke, Lacunar
/
Hematocrit
/
Homocysteine
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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