Your browser doesn't support javascript.
loading
Association Study of Functional Catechol-O-Methyltransferase Gene Polymorphism in Korean Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association ; : 708-717, 2001.
Article in Korean | WPRIM | ID: wpr-218518
ABSTRACT

OBJECTIVES:

Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine neurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls.

METHODS:

One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaIII and electrophoresis.

RESULTS:

No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4-fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 95% CI=1.10-14.33).

CONCLUSION:

Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Catechol O-Methyltransferase / Polymerase Chain Reaction / Age of Onset / Neurotransmitter Agents / Digestion / Electrophoresis / Alleles / Genotype / Inpatients Limits: Humans Language: Korean Journal: Journal of Korean Neuropsychiatric Association Year: 2001 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Schizophrenia / Catechol O-Methyltransferase / Polymerase Chain Reaction / Age of Onset / Neurotransmitter Agents / Digestion / Electrophoresis / Alleles / Genotype / Inpatients Limits: Humans Language: Korean Journal: Journal of Korean Neuropsychiatric Association Year: 2001 Type: Article