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Outcomes of Palliative Weekly Low-Dose Gemcitabine-Cisplatin Chemotherapy in Anthracycline- and Taxane- Pretreated Metastatic Breast Cancer Patients / 한국유방암학회지
Journal of Breast Cancer ; : 339-343, 2014.
Article in English | WPRIM | ID: wpr-218644
ABSTRACT

PURPOSE:

The combination of gemcitabine and cisplatin (GP) has been shown to be safe and efficacious for patients with metastatic breast cancer (MBC), pretreated with anthracyclines and taxanes. We assessed the efficacy and safety of weekly low-dose GP in patients with MBC.

METHODS:

We collected clinicopathological data from MBC patients who had been treated with gemcitabine, 800 mg/m2 plus cisplatin, 30 mg/m2 intravenously, on days 1 and 8 every 3 weeks, between January 2001 and November 2011 in Korea.

RESULTS:

The analysis included 294 patients previously treated anthracycline-xand taxane-based chemotherapies prior to GP (median age, 48 years [range, 28-78 years]; median follow-up duration, 63.9 months). Seventeen patients (5.8%) discontinued GP because of toxicities. The median progression-free survival (PFS) was 3.9 months (95% confidence interval [CI], 3.394.4 months) and the median overall survival (OS) was 27.7 months (95% CI, 17.6-37.8 months) months. Statistically significant factors for PFS were performance status (Eastern Cooperative Oncology Group, > or =2 vs. 2 years; HR, 1.66; 95% CI, 1.28-1.95, p1 year; HR, 1.48; 95% CI, 1.13-1.95, p2 years; HR, 2.07; 95% CI, 1.36-3.14; p<0.001) and the presence of brain metastasis (HR, 2.14; 95% CI, 1.27-3.61; p=0.004) were important factors for OS after GP treatment.

CONCLUSION:

Weekly low-dose GP chemotherapy appears safe and effective for heavily pretreated MBC patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain / Breast Neoplasms / Follow-Up Studies / Cisplatin / Disease-Free Survival / Anthracyclines / Taxoids / Diagnosis / Drug Therapy / Korea Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Breast Cancer Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Brain / Breast Neoplasms / Follow-Up Studies / Cisplatin / Disease-Free Survival / Anthracyclines / Taxoids / Diagnosis / Drug Therapy / Korea Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Journal of Breast Cancer Year: 2014 Type: Article