Nocturnal Gastroesophageal Reflux Revisited by Impedance-pH Monitoring
Journal of Neurogastroenterology and Motility
;
: 148-157, 2011.
Article
in English
| WPRIM
| ID: wpr-218798
ABSTRACT
BACKGROUND/AIMS:
Impedance-pH monitoring allows detailed characterization of gastroesophageal reflux and esophageal activity associated with reflux. We assessed the characteristics of nocturnal reflux and esophageal activity preceding and following reflux.METHODS:
Impedance-pH tracings from 11 healthy subjects and 76 patients with gastroesophageal reflux disease off acid-suppressive therapy were analyzed. Characteristics of nocturnal supine reflux, time distribution and esophageal activity seen on impedance at 2 minute intervals preceding and following reflux were described.RESULTS:
Patients had more nocturnal reflux events than healthy subjects (8 [4-12] vs 2 [1-5], P = 0.002), with lower proportion of weakly acidic reflux (57% [35-78] vs 80% [60-100], P = 0.044). Nocturnal reflux was mainly liquid (80%) and reached the proximal esophagus more often in patients (6% vs 0%, P = 0.047). Acid reflux predominated in the first 2 hours (66%) and weakly acidic reflux in the last 3 hours (70%) of the night. Most nocturnal reflux was preceded by aboral flows and cleared by short lasting volume clearance. In patients, prolonged chemical clearance was associated with less esophageal activity.CONCLUSIONS:
Nocturnal weakly acidic reflux is as common as acid reflux in patients with gastroesophageal reflux disease, and predominates later in the night. Impedance-pH can predict prolonged chemical clearance after nocturnal acid reflux.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gastroesophageal Reflux
/
Electric Impedance
/
Esophagus
/
Esophageal pH Monitoring
Limits:
Humans
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2011
Type:
Article
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