Serum serotonin concentration in small breed dogs with degenerative mitral valve disease / 동물의과학연구지
Journal of Biomedical Research
;
: 177-181, 2015.
Article
in English
| WPRIM
| ID: wpr-218819
ABSTRACT
This study investigated the potential associations of dog characteristics with serum serotonin (5HT) concentration in dogs with degenerative mitral valve disease (DMVD). Client-owned dogs were prospectively recruited at the Veterinary Medical Teaching Hospital of Chungnam National University between 2010 and 2011. Forty-two dogs (22 females and 20 males) were enrolled in this study. DMVD dogs included Maltese (n=12), followed by Shih-tzu (n=10), mixed breed (n=5), Chihuahua (n=4), Miniature schnauzer (n=3), Miniature poodle (n=3), Miniature pinscher (n=1), Pomeranian (n=1), Yorkshire terrier (n=2), and Spitz (n=1). As inclusion criteria for the study, dogs had to show either direct or echocardiographic evidence of DMVD. Platelet count significantly differed among the three groups, as the moderate (P<0.05) and severe groups (P<0.05) showed significantly higher platelet counts than the mild DMVD group. Additionally, significantly higher LVIDd, LVIDs, fractional shortening (FS), and LAAo ratios were observed in dogs with moderate (P<0.05) and severe (P<0.05) DMVD compared to the mild group, respectively. Significant positive correlations between serum 5-hydroxytryptamine (5HT) concentration and platelet count (r=0.273, P=0.03), LAAo ratio (r=0.459, P=0.001), and LVIDd (r=0.319, P=0.013) were observed in DMVD dogs. Therefore, serum 5HT concentration may be a potential cause of DMVD progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Blood Platelets
/
Echocardiography
/
Serotonin
/
Prospective Studies
/
Hospitals, Teaching
/
Mitral Valve
Type of study:
Observational study
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Journal of Biomedical Research
Year:
2015
Type:
Article
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