Impact of Metabolic Syndrome on Response to Medical Treatment of Benign Prostatic Hyperplasia
Korean Journal of Urology
;
: 814-820, 2014.
Article
in English
| WPRIM
| ID: wpr-219570
ABSTRACT
PURPOSE:
To investigate the effect of metabolic syndrome (MetS) on the response to medical therapy of benign prostatic hyperplasia (BPH) after a 3-month period of treatment. MATERIALS ANDMETHODS:
This was a cohort study of 100 patients, 47 with MetS and 53 without MetS, referred to either the primary care unit or referral hospital with BPH who had moderate lower urinary tract symptoms of prostate involvement and were candidates for medical treatment. Our main outcome was response to medical treatment with prazosin 1 mg twice a day and finasteride 5 mg daily in patients with BPH on the basis of International Prostate Symptom Score (IPSS). Multivariate analysis of covariance was used to compare BPH treatment response in patients with and without MetS before and after receiving treatment.RESULTS:
The mean volume of the prostate was significantly higher in MetS patients than in patients without MetS (57+/-32.65 mL compared with 46.00+/-20.19 mL, p=0.036). The control group demonstrated an 11-unit reduction in IPSS, whereas those with MetS showed a reduction in the symptom score of only 6 units (p<0.001). Regarding the components of MetS separately, triglyceride (p<0.001), fasting blood sugar (p=0.001), and waist circumference (p=0.028) significantly affected the clinical progression of BPH. The observational nature of this study may be a limitation in comparison with an interventional study.CONCLUSIONS:
The results of the present study showed that MetS can negatively affect the response to medical treatment of BPH. Therefore, it is necessary to consider MetS in selecting patients with BPH for drug therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Hyperplasia
/
Prazosin
/
Case-Control Studies
/
Treatment Outcome
/
Finasteride
/
Patient Selection
/
Metabolic Syndrome
/
Lower Urinary Tract Symptoms
/
Urological Agents
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Urology
Year:
2014
Type:
Article
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