Disseminated Penicilliosis in a Korean Human Immunodeficiency Virus Infected Patient from Laos
Journal of Korean Medical Science
;
: 697-700, 2012.
Article
in English
| WPRIM
| ID: wpr-21958
ABSTRACT
Penicillium marneffei may cause life-threatening systemic fungal infection in immune-compromised patients and it is endemic in Southeast Asia. A 39-yr-old HIV-infected male, living in Laos, presented with fever, cough, and facial vesiculopapular lesions, which had been apparent for two weeks. CT scans showed bilateral micronodules on both lungs; Pneumocystis jirovecii was identified by bronchoscopic biopsy. Despite trimethoprim-sulfamethoxazole and anti-tuberculosis medications, the lung lesions progressed and the facial lesions revealed central umbilications. Biopsy of the skin lesions confirmed disseminated penicilliosis, with the culture showing P. marneffei hyphae and spores. The P. marneffei was identified by rRNA PCR. A review of the bronchoscopic biopsy indicated penicilliosis. The patient completely recovered after being prescribed amphotericin-B and receiving antiretroviral therapy. This is the first case of penicilliosis in a Korean HIV-infected patient. It is necessary to consider P. marneffei when immunocompromised patients, with a history of visits to endemic areas, reveal respiratory disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillium
/
Bronchoscopy
/
Tomography, X-Ray Computed
/
HIV Infections
/
Amphotericin B
/
Immunocompromised Host
/
Anti-HIV Agents
/
Pneumocystis carinii
/
Dermatomycoses
/
Laos
Type of study:
Prognostic study
Limits:
Adult
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS