Role of murine Peyer's patch lymphocytes against primary and challenge infections with Cryptosporidium parvum
The Korean Journal of Parasitology
;
: 175-180, 2007.
Article
in English
| WPRIM
| ID: wpr-219745
ABSTRACT
In order to determine the role of Peyer's patch lymphocytes (PPL) in self-clearing of Cryptosporidium parvum infection in murine models, changes in PPL subsets, their cytokine expression, and in vitro IgG1 and IgA secretions by PPL were observed in primary- and challenge-infected C57BL/6 mice. In primary-infected mice, the percentages of CD4+ T cells, CD8+ T cells, sIgA+ B cells, IL-2+ T cells, and IFN-gamma+ T cells among the PPL, increased significantly (P 0.05) than those in primaryinfected mice. The results suggest that murine PPL play an important role in self-clearing of primary C. parvum infections through proliferation of CD4+, CD8+, IL-2+, and IFN-gamma+ T cells, and IgG1 and IgA-secreting B cells. In challenge infections, the role of T cells is reduced whereas that of B cells secreting IgA appeared to be continuously important.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peyer's Patches
/
Immunoglobulin A
/
Immunoglobulin G
/
Antibodies, Protozoan
/
Lymphocytes
/
Interferon-gamma
/
Interleukin-2
/
Cryptosporidium parvum
/
Specific Pathogen-Free Organisms
/
Cryptosporidiosis
Type of study:
Prognostic study
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS