Laser Doppler Estimated Cortical Hemodynamic Changes of Modified Fluid-Percussion Injury Model for Head Trauma Including Hyperosmolar Agent Infusion

ABSTRACT

A study of cortical blood flow changes using laser Doppler was conducted in seven head injuried rats with subsequent intravenous administration of mannitol. Cortical blood flow after head trauma by the fluid-percussion model was decreased in 6 cases and initially increased and then decreased in 1 case. Cortical blood flows were dramatically increased about three to six times after intravenous administration of mannitol. These results suggest that the modified fluid-percussion cortical injury system is more stable and consistent than the old fluid-percussion injury model. It, therefore, seems applicable to be used as experimental models for head trauma.