A case of celiac disease with neurologic manifestations misdiagnosed as amyotrophic lateral sclerosis
Intestinal Research
;
: 540-542, 2017.
Article
in English
| WPRIM
| ID: wpr-220091
ABSTRACT
Celiac disease (CD) is an immune-mediated enteropathy and is a rare disease in Asia, including in Korea. However, the ingestion of wheat products, which can act as a precipitating factor of CD, has increased rapidly. CD is a common cause of malabsorption, but many patients can present with various atypical manifestations as first presented symptoms, including anemia, osteopenia, infertility, and neurological symptoms. Thus, making a diagnosis is challenging. We report a case of CD that mimicked amyotrophic lateral sclerosis (ALS). The patient was a sexagenary man with a history of progressive motor weakness for 2 years. He was highly suspected as having ALS. During evaluation of his neurological symptoms, esophagogastroduodenoscopy (EGD) was performed because he had experienced loose stools and weight loss for the previous 7 months. On EGD, the duodenal mucosa appeared smooth. A biopsy revealed severe lymphoplasma cell infiltration with flattened villi. His serum endomysial antibody (immunoglobulin A) titer was 1160 (reference, <140). Finally, he was diagnosed as having CD, and a gluten-free diet was immediately begun. At a 4-month follow-up, his weight and the quality of his stool had improved gradually, and the neurological manifestations had not progressed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asia
/
Triticum
/
Biopsy
/
Bone Diseases, Metabolic
/
Weight Loss
/
Celiac Disease
/
Precipitating Factors
/
Follow-Up Studies
/
Endoscopy, Digestive System
/
Rare Diseases
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Intestinal Research
Year:
2017
Type:
Article
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