Epstein-Barr virus latent genes
Experimental & Molecular Medicine
;
: e131-2015.
Article
in English
| WPRIM
| ID: wpr-220402
ABSTRACT
Latent Epstein-Barr virus (EBV) infection has a substantial role in causing many human disorders. The persistence of these viral genomes in all malignant cells, yet with the expression of limited latent genes, is consistent with the notion that EBV latent genes are important for malignant cell growth. While the EBV-encoded nuclear antigen-1 (EBNA-1) and latent membrane protein-2A (LMP-2A) are critical, the EBNA-leader proteins, EBNA-2, EBNA-3A, EBNA-3C and LMP-1, are individually essential for in vitro transformation of primary B cells to lymphoblastoid cell lines. EBV-encoded RNAs and EBNA-3Bs are dispensable. In this review, the roles of EBV latent genes are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
RNA, Viral
/
Viral Matrix Proteins
/
Virus Latency
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Nuclear Antigens
/
Epstein-Barr Virus Infections
/
MicroRNAs
/
Genes, Viral
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS