Differences in the Prognosis according to the Periods of Diagnosis in Ulcerative Colitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 93-97, 2014.
Article
in Korean
| WPRIM
| ID: wpr-22047
ABSTRACT
BACKGROUND/AIMS:
Infliximab was approved for the treatment of ulcerative colitis (UC) in 2006 and has recently been used as rescue therapy in steroid-refractory UC. The aim of this study was to investigate the differences of medication use and prognosis in UC patients according to the periods of diagnosis.METHODS:
From 1987 to 2012, a total of 1,422 patients with UC were retrospectively reviewed in 12 hospitals. The study population was divided into two groups according to the periods of diagnosis as follows; group A 1987-2005, group B 2006-2012. Analyzed variables were compared by using chi-square test and logistic regression analysis.RESULTS:
Mean age of the subjects was 42.2 years, and the mean follow-up period was 4.7 years. In univariate analysis, the use of infliximab in group B was significantly higher than group A (4.5% vs. 7.6%, p=0.016), and UC-related hospitalization (45.8% vs. 40.1%, p=0.031) and UC-related surgery (6.4% vs. 3.5%, p=0.010) in group B was significantly lower than that of group A. The use of oral steroid in surgery group was significantly higher than non-surgery group in multivariate analysis (OR 1.85, 95% CI 1.03-3.30, p=0.039).CONCLUSIONS:
Infliximab might play an important role for the treatment of steroid-refractory UC. Well-designed prospective trials based on the efficacy and safety of infliximab are required in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Time Factors
/
Colitis, Ulcerative
/
Logistic Models
/
Odds Ratio
/
Anti-Inflammatory Agents, Non-Steroidal
/
Retrospective Studies
/
Follow-Up Studies
/
Mesalamine
/
Infliximab
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2014
Type:
Article
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