Expression of the ATP-gated P2X7 Receptor on M Cells and Its Modulating Role in the Mucosal Immune Environment
Immune Network
;
: 44-49, 2015.
Article
in English
| WPRIM
| ID: wpr-220543
ABSTRACT
Interactions between microbes and epithelial cells in the gastrointestinal tract are closely associated with regulation of intestinal mucosal immune responses. Recent studies have highlighted the modulation of mucosal immunity by microbe-derived molecules such as ATP and short-chain fatty acids. In this study, we undertook to characterize the expression of the ATP-gated P2X7 receptor (P2X7R) on M cells and its role in gastrointestinal mucosal immune regulation because it was poorly characterized in Peyer's patches, although purinergic signaling via P2X7R and luminal ATP have been considered to play an important role in the gastrointestinal tract. Here, we present the first report on the expression of P2X7R on M cells and characterize the role of P2X7R in immune enhancement by ATP or LL-37.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peyer's Patches
/
Phenobarbital
/
Adenosine Triphosphate
/
Immunity, Mucosal
/
Gastrointestinal Tract
/
Epithelial Cells
/
Fatty Acids, Volatile
/
Receptors, Purinergic P2X7
Language:
English
Journal:
Immune Network
Year:
2015
Type:
Article
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