Amiodarone Induced Blue-gray Pigmentation / 대한피부과학회지
Korean Journal of Dermatology
;
: 375-377, 2009.
Article
in Korean
| WPRIM
| ID: wpr-220746
ABSTRACT
Amiodarone (AD) is a benzofuran derivative that has been used for the treatment of recurrent arrhythmia and as a coronary vasodilator in Europe since 1964. AD-related hyperpigmentation develops after an average of 20 months of continuous AD treatment and with a minimal total dose of 160 g AD in less than 10% of the patients. A 49-year-old man presented with asymptomatic blue-gray patches that had slowly developed on the face over the previous 3 months. He had been taken amiodarone continuously for 39 months (cumulative dose 974 g). A skin lesion biopsy from the face showed many dermal melanophages containing brown granules. The AD was discontinued and he begin using sunscreen and is courrently being followed-up. The skin discoloration was still evident, but slightly diminished at five month's follow up.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Skin
/
Benzofurans
/
Biopsy
/
Pigmentation
/
Follow-Up Studies
/
Hyperpigmentation
/
Europe
/
Amiodarone
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Europa
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2009
Type:
Article
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