A Clinico-Epidemiological Study of Childhood Acute and Chronic Idiopathic Thrombocytopenic Purpura / 대한소아혈액종양학회지
Korean Journal of Pediatric Hematology-Oncology
;
: 1-10, 2005.
Article
in Korean
| WPRIM
| ID: wpr-220873
ABSTRACT
PURPOSE:
Childhood idiopathic thrombocytopenic purpura (ITP) is an acute, self-limited disease of several weeks, but 10~20% of cases may have chronic courses. This study was aimed to evaluate factors that might predict the progression to chronic ITP.METHODS:
Ninty-four patients with ITP were divided into acute and chronic on the basis of disease duration of 6 months. Clinical and laboratory characteristics were compared between the two groups. Response to intravenous immunoglobulin (IVIg) of either 400 mg/kg for 5 days or IVIg 1, 000 mg/kg for 2 days and progression to chronic ITP was compared.RESULTS:
67 cases (71.3%) were acute and 19 (28.7%) were chronic ITP. Sex, preceding viral infection history, clinical manifestations were not significantly different, but acute ITP was more prevalent in less than 1 year of age (P=.001). The initial WBC count was higher in acute than in chronic ITP (9, 600/microL vs. 7, 600/microL) (P .05). The relapse rate and progression to chronic ITP were not different.CONCLUSION:
The intial WBC counts, AST, MPV, the changes of hemoglobin level and MPV after IVIg infusion could be useful predictors of developing chronic ITP in children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Blood Platelets
/
Immunoglobulins
/
Purpura, Thrombocytopenic, Idiopathic
/
Immunoglobulins, Intravenous
Type of study:
Prognostic study
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatric Hematology-Oncology
Year:
2005
Type:
Article
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