Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 304-310, 2017.
Article
in English
| WPRIM
| ID: wpr-220957
ABSTRACT
BACKGROUND:
Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome.METHODS:
The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses.RESULTS:
The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second (FEV₁, L), and FEV₁ (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count.CONCLUSION:
The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Respiratory Function Tests
/
Smoke
/
Smoking
/
Linear Models
/
Vital Capacity
/
Risk Factors
/
Pulmonary Disease, Chronic Obstructive
/
Leukocyte Count
/
Leukocytes
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2017
Type:
Article
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