Clinical Efficacy of Carvedilol in Patients with Moderate to Severe Congestive Heart Failure
Korean Circulation Journal
;
: 523-531, 1998.
Article
in Korean
| WPRIM
| ID: wpr-220991
ABSTRACT
BACKGROUND:
Clinical trials have shown that b-adrenergic blocking drugs are effective and well tolerated in patients with mild to moderate congestive heart failure. Carvedilol is a mild b1-selective adrenergic blocking agent with vasodilating properties due to a blocker and antioxidant and anti-proliferative properties. This study assessed the efficacy and safety of carvedilol in patients with moderate to severe congestive heart failure caused by idiopathic dilated cardiomyopathy.METHODS:
We enrolled 27 patients with moderate to severe congestive heart failure with a left ventricular ejection fraction of 35% by MUGA scan. Each patient was randomly assigned to either control (n-9) or carvedilol (n-18, target dose 25 mg bid) for 6 months while background therapy with digoxin, diuretics, and ACE inhibitor remained constant.RESULTS:
Compared to the control group, patients in the carvedilol group showed significant increase of left ventricular ejection fraction (p<0.05). In addition, patients in the carvedilol group had a tendency to show a decrease in left ventricular end-diastolic dimension and heart rate. Also, the carvedilol group had a greater frequency of symptomatic improvement than the control group. There was neither serious side effects nor hospitalization.CONCLUSION:
These finding indicate that carvedilol produces important clinical benefits in patients with moderate to severe heart failure treated with digoxin, diuretics, and ACE inhibitor without serious side effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stroke Volume
/
Cardiomyopathy, Dilated
/
Digoxin
/
Diuretics
/
Heart Failure
/
Heart Rate
/
Hospitalization
Limits:
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1998
Type:
Article
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