Alteration of Ventricular Repolarization by Intracoronary Infusion of Normal Saline in Patients With Variant Angina
Korean Circulation Journal
;
: 223-227, 2009.
Article
in English
| WPRIM
| ID: wpr-221156
ABSTRACT
BACKGROUND AND OBJECTIVES:
During coronary angiography and interventional procedures, catheters that are engaged in a coronary ostium are routinely flushed, typically with normal saline, to expel blood from the catheter or to inject a pharmacologic agent. Saline contains sodium and chloride ions. Such injections may affect the electrophysiologic properties of the myocardium; however, the effect of normal saline on ventricular repolarization has not been established in patients with variant angina. SUBJECTS ANDMETHODS:
We studied 51 consecutive patients with variant angina. Five mL of normal saline (NS) or 5% dextrose solution (DW) were infused into the left coronary artery in random order. We measured the heart rate, QT interval, and T-wave amplitude using Mac-Lac 5.2.RESULTS:
The baseline clinical characteristics were not different between the NS {n=30 (14 males); mean age, 56+/-10 years} and the 5% DW groups {n=21 (7 males); mean age, 59+/-10 years}. The changes in the mean corrected QT (QTc) interval were significantly increased at the time of infusion of NS compared to 5% DW (45.1+/-30.3 vs. 20.9+/-23.3 ms, p=0.004). There was a T-wave amplitude change >0.2 mV in at least one-lead in 27 patients (90.0%) during NS infusion compared to 7 patients (33.3%) during 5% DW infusions (p=0.001). No significant changes in heart rate and blood pressure were noted during of the infusions.CONCLUSION:
NS was associated with prolongation of ventricular repolarization in patients with variant angina.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sodium
/
Blood Pressure
/
Angiography
/
Sodium Chloride
/
Coronary Angiography
/
Coronary Vessels
/
Catheters
/
Glucose
/
Heart Rate
/
Ions
Limits:
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2009
Type:
Article
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