The Effects of Alfentanil and a Combination of Alfentanil and Esmolol on Hemodynamic Responses after Endotracheal Intubation in Hypertensive Patients / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 136-141, 2005.
Article
in Korean
| WPRIM
| ID: wpr-221263
ABSTRACT
BACKGROUND:
This study was desined to determine the efficacy and clincial usefulness of alfentanil and a combined use of alfentanil and esmolol for blunting hemodynamic responses after tracheal intubation in hypertensive patients who needed a rapid sequence induction.METHODS:
Group 1 received alfentanil 15microgram/kg and group 2 received alfentanil 15microgram/kg and esmolol 1 mg/kg intravenously. Thiopental sodium 5 mg/kg and succinylcholine 1 mg/kg were used for the induction of anesthesia. Changes in blood pressure and herat rate were measured during intubation and induction of anesthesia with enflurane-N2O-O2 and vecuronium. Rate pressure products (RPP) was calculated and the frequencies of hypertension, hypotension, tachycardia, bradycardia were measured.RESULTS:
In group 1, systolic blood pressure increased significantly at 1, 2 minute and decreased significantly at 4, 5, 10, 15 minute compared to base, and diastolic blood pressure increased significantly at 1 minute and decreased significantly at 4, 5, 10 minute. Heart rate increased significantly at 1, 2 minute. In group 2, systolic blood pressure decrease significantly at 3, 4, 5 minute after tracheal intubation compared to base, and diastolic blood pressure increased at 1 minute and decreased at 4, 5, 10, 15 minute. HR did not change significantly (P < 0.05).CONCLUSION:
In treated hypertensive patients, the use of a combination of alfentanil 15/kg and esmolol 1 mg/kg is a useful method to attenuate hemodynamic responses after endotracheal intubation and especially for rapid sequence induction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Succinylcholine
/
Tachycardia
/
Thiopental
/
Blood Pressure
/
Vecuronium Bromide
/
Bradycardia
/
Alfentanil
/
Heart Rate
/
Hemodynamics
/
Hypertension
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article
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