Korean Guideline for Iron Chelation Therapy in Transfusion-Induced Iron Overload
Journal of Korean Medical Science
;
: 1563-1572, 2013.
Article
in English
| WPRIM
| ID: wpr-221307
ABSTRACT
Many Korean patients with transfusion-induced iron overload experience serious clinical sequelae, including organ damage, and require lifelong chelation therapy. However, due to a lack of compliance and/or unavailability of an appropriate chelator, most patients have not been treated effectively. Deferasirox (DFX), a once-daily oral iron chelator for both adult and pediatric patients with transfusion-induced iron overload, is now available in Korea. The effectiveness of deferasirox in reducing or maintaining body iron has been demonstrated in many studies of patients with a variety of transfusion-induced anemias such as myelodysplastic syndromes, aplastic anemia, and other chronic anemias. The recommended initial daily dose of DFX is 20 mg/kg body weight, taken on an empty stomach at least 30 min before food and serum ferritin levels should be maintained below 1000 ng/mL. To optimize the management of transfusion-induced iron overload, the Korean Society of Hematology Aplastic Anemia Working Party (KSHAAWP) reviewed the general consensus on iron overload and the Korean data on the clinical benefits of iron chelation therapy, and developed a Korean guideline for the treatment of iron overload.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyridones
/
Triazoles
/
Benzoates
/
Blood Transfusion
/
Myelodysplastic Syndromes
/
Chelation Therapy
/
Iron Chelating Agents
/
Iron Overload
/
Republic of Korea
/
Anemia, Aplastic
Type of study:
Practice guideline
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2013
Type:
Article
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