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4-Hydroxybenzaldehyde, One of Constituents from Gastrodiae Rhizoma Augments Pentobarbital-induced Sleeping Behaviors and Non-rapid Eye Movement (NREM) Sleep in Rodents
Natural Product Sciences ; : 219-225, 2015.
Article in English | WPRIM | ID: wpr-221413
ABSTRACT
In the previous experiments, we reported that ethanol extract of Gastrodiae Rhizoma, the dried tuber of Gastrodia ElataBlume (Orchidaceae) increased pentobarbital-induced sleeping behaviors. These experiments were undertaken to know whether 4-hydroxybenzaldehyde (4-HBD), is one of the major compounds of Gastrodiae Rhizoma increases pentobarbital-induced sleeping behaviors and changes sleep architectures via activating GABA(A)-ergic systems in rodents. 4-HBD decreased locomotor activity in mice. 4-HBD increased total sleep time, and decreased of sleep onset by pentobarbital (28 mg/kg and 40 mg/kg). 4-HBD showed synergistic effects with muscimol (a GABA(A) receptor agonist), shortening sleep onset and enhancing sleep time on pentobarbital-induced sleeping behaviors. On the other hand, 4-HBD (200 mg/kg, p.o.) itself significantly inhibited the counts of sleep-wake cycles, and prolonged total sleep time and non-rapid eye movement (NREM) in rats. Moreover, 4-HBD increased intracellular Cl- levels in the primary cultured cerebellar cells. The protein levels of glutamic acid decarboxylase (GAD) and GABA(A) receptors subunits were over-expressed by 4-HBD. Consequently, these results demonstrate that 4-HBD increased NREM sleep as well as sleeping behaviors via the activation of GABA(A)-ergic systems in rodents.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pentobarbital / Rodentia / Receptors, GABA-A / Gastrodia / Ethanol / Eye Movements / Glutamate Decarboxylase / Hand / Motor Activity / Muscimol Limits: Animals Language: English Journal: Natural Product Sciences Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pentobarbital / Rodentia / Receptors, GABA-A / Gastrodia / Ethanol / Eye Movements / Glutamate Decarboxylase / Hand / Motor Activity / Muscimol Limits: Animals Language: English Journal: Natural Product Sciences Year: 2015 Type: Article