Dose - response for Glycopyrrloate and Heart Rate in Children Anesthetized with Halothane and Nitrous Oxide / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 243-249, 1993.
Article
in Korean
| WPRIM
| ID: wpr-221529
ABSTRACT
The dose-response for glycopyrrolate and heart rate in anesthetized children has not heen defined. We determined the dose-response for glyeopyrrolate and heart rate in 50 children, ASA physical status l and 2, anesthetized with halothane and nitrous oxide. Anesthesia was induced with 60-70% nitrous oxide in oxygen and halothane(1.5-2.0 vo1%). After induction of aneethesia, glycopyrrolate in a dose of 4, 6, 8, 12 or 16ug Xkg(-1) was administered by rapid infusion to each subject. The effects of glycopyrrolate on heart rate, heart rhythm and systolic blood pressure were compared among dosage groups, and dose-response curve for peak heart rate was constructed, Glycopyrrolate increased the heart rate in a dose-related manner upto 12 ug X kg(-1) except 16 ugX kg(-1). Fifty percent maximal response corresponded to 6.1 ug X kg(-1), and 95% maximal response corresponded to 11.1 ug X kg(-1) . None of the patients had nonsinus rhythm after glycopyrrolate injection. Except for glycopyrrolate given at 4 ug x kg(-1), the systolic blood pressure increased significantly after all other doses. Glycopyrrolate in doses greater than or equal to 6 ug X kg(-1) increased the heart rate and systolic blood pressure in children anesthetized with halothane and nitrous oxide.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Blood Pressure
/
Glycopyrrolate
/
Halothane
/
Heart
/
Heart Rate
/
Anesthesia
/
Anesthetics
/
Nitrous Oxide
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1993
Type:
Article
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