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Prognostic significance of neutropenia during adjuvant concurrent chemoradiotherapy in early cervical cancer / 부인종양
Journal of Gynecologic Oncology ; : 146-150, 2009.
Article in English | WPRIM | ID: wpr-221571
ABSTRACT

OBJECTIVE:

To evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine cervix.

METHODS:

Data from 107 patients with stage IB-IIB cervical cancer were retrospectively analyzed. The median follow-up was 37.5 (4.2-72.7) months. All patients had received radical surgery, including pelvic lymphadenectomy, followed by paclitaxel plus carboplatin-based concurrent chemoradiotherapy. Relative neutropenia, defined as an absolute neutrophil count <1,000/mm3 at the concurrent chemoradiotherapy cycle nadir, correlated to the pathologic findings and survival outcomes.

RESULTS:

Sixty-six patients experienced neutropenia at least once during concurrent chemoradiotherapy, and demonstrated marginal improvement in disease-free survival (p=0.055), although not in overall survival. By subgroup analyses, the gain of disease free survival mainly originated from the node metastasis subgroup (p=0.033). Treatment-induced neutropenia proved to be the only significant independent factor for recurrence in cervical cancer (p=0.042) by multivariate analysis.

CONCLUSION:

Concurrent chemoradiotherapy-induced neutropenia may be a prognostic factor of recurrence in patients with cervical cancer. Individualized dose titration of the tolerable myelosuppression might be beneficial.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Carcinoma, Squamous Cell / Uterine Cervical Neoplasms / Cervix Uteri / Multivariate Analysis / Retrospective Studies / Follow-Up Studies / Paclitaxel / Disease-Free Survival / Chemoradiotherapy Type of study: Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Carcinoma, Squamous Cell / Uterine Cervical Neoplasms / Cervix Uteri / Multivariate Analysis / Retrospective Studies / Follow-Up Studies / Paclitaxel / Disease-Free Survival / Chemoradiotherapy Type of study: Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Journal of Gynecologic Oncology Year: 2009 Type: Article