Prognostic significance of neutropenia during adjuvant concurrent chemoradiotherapy in early cervical cancer / 부인종양
Journal of Gynecologic Oncology
;
: 146-150, 2009.
Article
in English
| WPRIM
| ID: wpr-221571
ABSTRACT
OBJECTIVE:
To evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine cervix.METHODS:
Data from 107 patients with stage IB-IIB cervical cancer were retrospectively analyzed. The median follow-up was 37.5 (4.2-72.7) months. All patients had received radical surgery, including pelvic lymphadenectomy, followed by paclitaxel plus carboplatin-based concurrent chemoradiotherapy. Relative neutropenia, defined as an absolute neutrophil count <1,000/mm3 at the concurrent chemoradiotherapy cycle nadir, correlated to the pathologic findings and survival outcomes.RESULTS:
Sixty-six patients experienced neutropenia at least once during concurrent chemoradiotherapy, and demonstrated marginal improvement in disease-free survival (p=0.055), although not in overall survival. By subgroup analyses, the gain of disease free survival mainly originated from the node metastasis subgroup (p=0.033). Treatment-induced neutropenia proved to be the only significant independent factor for recurrence in cervical cancer (p=0.042) by multivariate analysis.CONCLUSION:
Concurrent chemoradiotherapy-induced neutropenia may be a prognostic factor of recurrence in patients with cervical cancer. Individualized dose titration of the tolerable myelosuppression might be beneficial.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Paclitaxel
/
Disease-Free Survival
/
Chemoradiotherapy
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Gynecologic Oncology
Year:
2009
Type:
Article
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