Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
Yonsei Medical Journal
;
: 1562-1567, 2014.
Article
in English
| WPRIM
| ID: wpr-221606
ABSTRACT
PURPOSE:
This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS ANDMETHODS:
A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.RESULTS:
Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.CONCLUSION:
The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Pregnancy Complications, Infectious
/
Pregnancy Trimester, First
/
Uterus
/
Immunohistochemistry
/
Prevalence
/
Prospective Studies
/
Sequence Analysis, DNA
/
Enterovirus B, Human
/
Abortion, Missed
Type of study:
Observational study
/
Prevalence study
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2014
Type:
Article
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