Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
Yonsei Medical Journal
;
: 1507-1515, 2014.
Article
in English
| WPRIM
| ID: wpr-221612
ABSTRACT
PURPOSE:
Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) binds to low-density lipoprotein. The levels of Lp-PLA2 reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS ANDMETHODS:
We classified 226 study participants into three groups patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group).RESULTS:
Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA2 levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA2 to the ACS model significantly increased the global chi2 value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA2 was 0.624 (p=0.004). The addition of Lp-PLA2 level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error 0.0142) and improved the ability to diagnose ACS.CONCLUSION:
Lp-PLA2 levels are related to plaque stability and might be a diagnostic biomarker for ACS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
C-Reactive Protein
/
Biomarkers
/
Logistic Models
/
Multivariate Analysis
/
Risk Factors
/
ROC Curve
/
Coronary Angiography
/
1-Alkyl-2-acetylglycerophosphocholine Esterase
/
Acute Coronary Syndrome
/
Plaque, Atherosclerotic
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2014
Type:
Article
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