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Lipoprotein-Associated Phospholipase A2 Is Related to Plaque Stability and Is a Potential Biomarker for Acute Coronary Syndrome
Yonsei Medical Journal ; : 1507-1515, 2014.
Article in English | WPRIM | ID: wpr-221612
ABSTRACT

PURPOSE:

Plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) binds to low-density lipoprotein. The levels of Lp-PLA2 reflect the plaque burden, and are upregulated in acute coronary syndrome (ACS). We investigated the diagnostic value of Lp-PLA2 levels and found that it might be a potential biomarker for ACS. MATERIALS AND

METHODS:

We classified 226 study participants into three groups patients without significant stenosis (control group), patients with significant stenosis with stable angina (SA group), and patients with ACS (ACS group).

RESULTS:

Lp-PLA2 and high-sensitivity C-reactive protein (hs-CRP) levels were significantly greater in the ACS group than in the SA group (p=0.044 and p=0.029, respectively). Multivariate logistic regression analysis revealed that Lp-PLA2 levels are significantly associated with ACS (odds ratio=1.047, p=0.013). The addition of Lp-PLA2 to the ACS model significantly increased the global chi2 value over traditional risk factors (28.14 to 35.602, p=0.006). The area under the receiver operating characteristic curve for Lp-PLA2 was 0.624 (p=0.004). The addition of Lp-PLA2 level to serum hs-CRP concentration yielded an integrated discrimination improvement of 0.0368 (p=0.0093, standard error 0.0142) and improved the ability to diagnose ACS.

CONCLUSION:

Lp-PLA2 levels are related to plaque stability and might be a diagnostic biomarker for ACS.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: C-Reactive Protein / Biomarkers / Logistic Models / Multivariate Analysis / Risk Factors / ROC Curve / Coronary Angiography / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Acute Coronary Syndrome / Plaque, Atherosclerotic Type of study: Etiology study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: C-Reactive Protein / Biomarkers / Logistic Models / Multivariate Analysis / Risk Factors / ROC Curve / Coronary Angiography / 1-Alkyl-2-acetylglycerophosphocholine Esterase / Acute Coronary Syndrome / Plaque, Atherosclerotic Type of study: Etiology study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Language: English Journal: Yonsei Medical Journal Year: 2014 Type: Article