White Blood Cell Count to Mean Platelet Volume Ratio Is a Prognostic Factor in Patients with Non-ST Elevation Acute Coronary Syndrome with or without Metabolic Syndrome
Korean Circulation Journal
;
: 229-238, 2016.
Article
in English
| WPRIM
| ID: wpr-221723
ABSTRACT
BACKGROUND AND OBJECTIVES:
Leukocyte and platelet have been found to be associated with metabolic syndrome (MetS). We aimed to determine the usefulness of a novel marker named white blood cell count to mean platelet volume ratio (WMR) for predicting outcomes of non-ST elevation acute coronary syndrome (NSTE-ACS) with or without MetS. SUBJECTS ANDMETHODS:
A total of 331 NSTE-ACS individuals (60±12.5 years, 57.4% male) were enrolled and followed for a median of 24 months. MetS was identified using the National Cholesterol Education Program Adult Treatment Panel III criteria.RESULTS:
Patients were divided into two groups high WMR (WMR≥720) and low WMR (WMR<720). Major adverse cardiovascular events (MACE) and MetS rates were significantly greater in the higher WMR group compared to those in the low WMR group (MACE 14.3% vs. 25%, p=0.014; MetS 50.9% vs. 75%, p<0.001). MetS was diagnosed in 62.2% of patients. MACE incidence in patients with or without MetS was comparable (p=0.737). Among MetS individuals, patients in the high WMR group had more MACE than the low WMR group (11.2% vs. 26.5%, p=0.007). However, MACE was comparable among non-MetS individuals (p=0.681). In multivariable Cox regression analysis, hazard ratios (HR) of MACE incidence for high-WMR in MetS individuals was 2.616 (95% confidence interval 1.282–5.339, p=0.008). However, HR of MACE incidence for high WMR in non-MetS individuals was not significant.CONCLUSION:
Among NSTE-ACS patients without revascularization therapy, elevated admission WMR was associated with an increased risk of developing composite MACE in MetS individuals but not in non-MetS patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Platelets
/
Cholesterol
/
Incidence
/
Education
/
Acute Coronary Syndrome
/
Mean Platelet Volume
/
Inflammation
/
Leukocyte Count
/
Leukocytes
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Korean Circulation Journal
Year:
2016
Type:
Article
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