Management consideration in nonpulmonary visceral metastatic seminoma of testis
Journal of Korean Medical Science
;
: 431-437, 1999.
Article
in English
| WPRIM
| ID: wpr-221959
ABSTRACT
To develop a more appropriate therapeutic strategy for treatment of nonpulmonary visceral metastatic testicular seminoma based on the International Germ Cell Consensus Classification, we reviewed the medical records of patients with nonpulmonary visceral metastatic testicular seminoma who were treated over a 20-year period. Only 15 (2.2%) of the 686 cases of testicular seminoma were nonpulmonary visceral metastatic seminoma. The median age of patients was 38 years (range, 22-53 years). Ten (67%) of the patients had an initial diagnosis of supradiaphragmatic or visceral metastatic disease. In addition to nonpulmonary visceral metastasis, all patients had lymph node metastasis as well, the majority of which involved the retroperitoneal lymph nodes. The median and mean progression-free survival durations after chemotherapy for advanced disease were 19 months and 63.7 months, respectively. Six patients (40%) survived, five relapsed after radiation therapy and four died of chemorefractory disease not dependent on the specific regimen. Although the number of cases reviewed in this study was small, we conclude that the choice of chemotherapeutic regimen among the current treatments for nonpulmonary visceral metastatic seminoma of testis primary does not present a different outcome. Therefore, multimodality therapies using new strategies or new agents are well indicated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retroperitoneal Neoplasms
/
Testicular Neoplasms
/
Bone Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Retrospective Studies
/
Seminoma
/
Combined Modality Therapy
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Middle Aged
Type of study:
Observational study
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
1999
Type:
Article
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