Eosinophils and Type 2 Cytokine Signaling in Macrophages Support the Biogenesis of Cold-induced Beige Fat
Journal of Bacteriology and Virology
;
: 44-46, 2016.
Article
in English
| WPRIM
| ID: wpr-221988
ABSTRACT
Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organelle Biogenesis
/
Adipose Tissue, Brown
/
Catecholamines
/
Cytokines
/
Adipocytes
/
Thermogenesis
/
Eosinophils
/
Adipose Tissue, White
/
Fatty Acids
/
Hot Temperature
Language:
English
Journal:
Journal of Bacteriology and Virology
Year:
2016
Type:
Article
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