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Yersinia enterocolitica Exploits Signal Crosstalk between Complement 5a Receptor and Toll-like Receptor 1/2 and 4 to Avoid the Bacterial Clearance in M cells
Immune Network ; : 228-236, 2017.
Article in En | WPRIM | ID: wpr-22202
Responsible library: WPRO
ABSTRACT
In the intestinal mucosal surface, microfold cells (M cells) are the representative gateway for the uptake of luminal antigens. At the same time, M cells are the primary infection site for pathogens invading mucosal surface for their infection. Although it is well recognized that many mucosal pathogens exploit the M cells for their infection, the mechanism to infect M cells utilized by pathogens is not clearly understood yet. In this study, we found that M cells expressing complement 5a (C5a) receptor (C5aR) also express Toll-like receptor (TLR) 1/2 and TLR4. Infection of Yersinia enterocolitica, an M cell-invading pathogen, synergistically regulated cyclic adenosine monophosphate-dependent protein kinase A (cAMP-PKA) signaling which are involved in signal crosstalk between C5aR and TLRs. In addition, Y. enterocolitica infection into M cells was enhanced by C5a treatment and this enhancement was abrogated by C5a antagonist treatment. Finally, Y. enterocolitica infection into M cells was unsuccessful in C5aR knock-out mice. Collectively, we suggest that exploit the crosstalk between C5aR and TLR signaling is one of infection mechanisms utilized by mucosal pathogens to infect M cells.
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Full text: 1 Index: WPRIM Main subject: Phenobarbital / Yersinia / Yersinia enterocolitica / Complement System Proteins / Complement C5a / Adenosine / Mice, Knockout / Cyclic AMP-Dependent Protein Kinases / Receptor, Anaphylatoxin C5a / Toll-Like Receptors Limits: Animals Language: En Journal: Immune Network Year: 2017 Type: Article
Full text: 1 Index: WPRIM Main subject: Phenobarbital / Yersinia / Yersinia enterocolitica / Complement System Proteins / Complement C5a / Adenosine / Mice, Knockout / Cyclic AMP-Dependent Protein Kinases / Receptor, Anaphylatoxin C5a / Toll-Like Receptors Limits: Animals Language: En Journal: Immune Network Year: 2017 Type: Article