Immune response to 19A serotype after immunization of 19F containing pneumococcal conjugate vaccine in Korean children aged 12-23 months / 소아과
Korean Journal of Pediatrics
;
: 163-168, 2011.
Article
in English
| WPRIM
| ID: wpr-222091
ABSTRACT
PURPOSE:
The purpose of this study was to evaluate the immune response to serotype 19A in children aged 12-23 months after immunization of the 19F containing 7-valent pneumococcal conjugate vaccine (PCV7).METHODS:
Blood samples from a total of 45 subjects (age 12-23 months) were included in the study. Subjects were categorized according to immunization status into three groups as follows 18 subjects with 3 primary doses and 1 booster dose of PCV7 (booster group), 21 subjects with 3 primary doses before 12 months of age (primary group), and 6 subjects with no vaccination history of PCV7 (control group). An ELISA and opsonophagocytic killing assay (OPKA) was done to evaluate the immune responses against serotypes 19F and 19A.RESULTS:
According to the ELISA, all subjects had antibody titers > or =0.35 microg/mL for serotypes 19F and 19A in the booster and primary group and 83.0% and 66.7% in the control group, respectively. According to the OPKA, subjects with opsonic activity (> or =20) against serotypes 19F and 19A were 100% and 61.1% of the subjects in the booster group and 66.7% and 19.0% in the primary group, respectively. No subjects in the control group had opsonic antibodies against both serotypes.CONCLUSION:
In conclusion, in children 12-23 months age who were previously vaccinated with PCV7, a cross-reactive immune response is elicited against serotype 19A after a primary series of 3 doses in a small proportion of subjects, and this response is amplified after booster vaccination.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptococcus pneumoniae
/
Enzyme-Linked Immunosorbent Assay
/
Immunization
/
Vaccination
/
Pneumococcal Vaccines
/
Heptavalent Pneumococcal Conjugate Vaccine
/
Homicide
/
Antibodies
/
Antibody Formation
Limits:
Aged
/
Child
/
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2011
Type:
Article
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