Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
Journal of Menopausal Medicine
;
: 69-73, 2017.
Article
in English
| WPRIM
| ID: wpr-222375
ABSTRACT
We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Immunohistochemistry
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Endometrial Neoplasms
/
Colon
/
Colonic Neoplasms
/
Germ-Line Mutation
/
Siblings
/
Genetic Counseling
/
Korea
Type of study:
Diagnostic study
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Menopausal Medicine
Year:
2017
Type:
Article
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