Case Report of Menopausal Woman Diagnosed with Endometrial Cancer after Colon Cancer with Germline Mutation in MSH6 in Korea
Journal of Menopausal Medicine
; : 69-73, 2017.
Article
in En
| WPRIM
| ID: wpr-222375
Responsible library:
WPRO
ABSTRACT
We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c. 3261dupC).
Key words
Full text:
1
Index:
WPRIM
Main subject:
Immunohistochemistry
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Endometrial Neoplasms
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Colon
/
Colonic Neoplasms
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Germ-Line Mutation
/
Siblings
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Genetic Counseling
/
Korea
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Menopausal Medicine
Year:
2017
Type:
Article